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How to synthesize native and modified proteins in the test tubeA With contributions from a panel of experts representing a range ofA disciplines,A Total Chemical Synthesis of ProteinsA presents aA carefully curatedA collection of synthetic approaches and strategies for the total synthesis of native and modified proteins.A A A Comprehensive in scope, thisA important reference explores the three main chemoselective ligation methods for assembling unprotected peptide segments, including native chemical ligation (NCL).A ItA includes information on synthetic strategies for the complex polypeptides that constitute glycoproteins, sulfoproteins, and membrane proteins, as well as their characterization.
In addition, important areas of application for total protein synthesis are detailed, such as protein crystallography, protein engineering, and biomedical research.A The authors also discuss the synthetic challenges that remain to be addressed.
ThisA unmatchedA resource:A ContainsA valuable insightsA fromA theA pioneers in theA field ofA chemical protein synthesisA PresentsA provenA syntheticA approachesA forA a range of protein familiesA ExploresA keyA applications of precisely controlled protein synthesis, includingA novel diagnostics and therapeuticsA Written for organic chemists, biochemists, biotechnologists, and molecular biologists,A Total Chemical Synthesis of ProteinsA provides key knowledge forA everyone venturing intoA the burgeoning field ofA protein design and synthetic biology.A A A
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