Evolution of Translational Omics : Lessons Learned and the Path Forward PDF
by Institute of Medicine, Board on Health Sciences Policy, Board on Health Care Services, Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials
Edited by Gilbert S. Omenn, Sharly J. Nass, Christine M. Micheel
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Description
Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.
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- Format:PDF
- Pages:354 pages
- Publisher:National Academies Press
- Publication Date:13/08/2012
- Category:
- ISBN:9780309224192
Information
-
Download Now
- Format:PDF
- Pages:354 pages
- Publisher:National Academies Press
- Publication Date:13/08/2012
- Category:
- ISBN:9780309224192