Carbonic Anhydrase as Drug Target : Thermodynamics and Structure of Inhibitor Binding Hardback
Edited by Daumantas Matulis
Hardback
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Description
This book offers deep insights into the thermodynamics and molecular structures of the twelve catalytically active isoforms of human carbonic anhydrase (CA) with a particular focus on inhibitor binding for drug design.
X-ray crystallographic structures in combination with enzyme kinetic testing provide information on the interaction of CAs and their inhibitors, knowledge which is crucial for rational drug design. CAs are zinc carrying enzymes that catalyse the reversible interconversion of carbon dioxide and bicarbonate and are involved in numerous cellular processes.
They are therefore a common target for drugs. The suppression of CA activities through inhibitory compounds has found application for example in diuretics and in glaucoma therapy.
In this book methods used to determine binding thermodynamics of inhibitory compounds (Isothermal titration calorimetry, Fluorescent thermal shift assay/differential scanning fluorimetry and others) will be compared in detail.
Also typesand chemical synthesis of CA inhibitors, the use of antibodies against CAs as well as inhibitor application in animals are discussed.
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Out of StockMore expected soonContact us for further information
- Format:Hardback
- Pages:353 pages, 107 Illustrations, color; 62 Illustrations, black and white; XXVI, 353 p. 169 illus., 107
- Publisher:Springer Nature Switzerland AG
- Publication Date:03/06/2019
- Category:
- ISBN:9783030127787
Information
-
Out of StockMore expected soonContact us for further information
- Format:Hardback
- Pages:353 pages, 107 Illustrations, color; 62 Illustrations, black and white; XXVI, 353 p. 169 illus., 107
- Publisher:Springer Nature Switzerland AG
- Publication Date:03/06/2019
- Category:
- ISBN:9783030127787