Accounts in Drug Discovery : Case Studies in Medicinal Chemistry Hardback
Edited by Joel (Bristol-Myers Squibb, USA) Barrish, Percy (Bristol-Myers Squibb, USA) Carter, Peter (Bristol-Myers Squibb, USA) Cheng, Robert Zahler
Part of the Drug Discovery series
Hardback
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Description
Accounts in Drug Discovery describes recent case studies in medicinal chemistry with a particular emphasis on how the inevitable problems that arise during any project can be surmounted or overcome.
The Editors cover a wide range of therapeutic areas and medicinal chemistry strategies, including lead optimization starting from high throughput screening "hits" as well as rational, structure-based design.
The chapters include "follow-ons" and "next generation" compounds that aim to improve upon first generation agents.
This volume surveys the range of challenges commonly faced by medicinal chemistry researchers, including the optimization of metabolism and pharmacokinetics, toxicology, pharmaceutics and pharmacology, including proof of concept in the clinic for novel biological targets.
The case studies include medicinal chemistry stories on recently approved and marketed drugs, but also chronicle "near-misses", i.e., exemplary compounds that may have proceeded well into the clinic but for various reasons did not result in a successful registration.
As the vast majority of projects fail prior to registration, much can be learned from such narratives.
By sharing a wide range of drug discovery experiences and information across the community of medicinal chemists in both industry and academia, we believe that these accounts will provide insights into the art of medicinal chemistry as it is currently practiced and will help to serve the needs of active medicinal chemists.
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Out of Stock - We are unable to provide an estimated availability date for this product
- Format:Hardback
- Pages:370 pages, No
- Publisher:Royal Society of Chemistry
- Publication Date:30/09/2010
- Category:
- ISBN:9781849731263
Information
-
Out of Stock - We are unable to provide an estimated availability date for this product
- Format:Hardback
- Pages:370 pages, No
- Publisher:Royal Society of Chemistry
- Publication Date:30/09/2010
- Category:
- ISBN:9781849731263