Comprehensive Analysis of Parasite Biology : From Metabolism to Drug Discovery, Hardback Book

Comprehensive Analysis of Parasite Biology : From Metabolism to Drug Discovery Hardback

Edited by Sylke Muller, Rachel Cerdan, Ovidiu Radulescu

Part of the Drug Discovery in Infectious Diseases series

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Written and edited by experts in the field, this book brings together the current state of the art in phenotypic and rational, target-based approaches to drug discovery against pathogenic protozoa.

The chapters focus particularly on virtual compounds and high throughput screening, natural products, computer-assisted drug design, structure-based drug design, mechanism of action identification, and pathway modelling.

Furthermore, state-of the art "omics" technologies are described and currently studied enzymatic drug targets are discussed.

Mathematical, systems biology-based approaches are introduced as new methodologies for dissecting complex aspects of pathogen survival mechanisms and for target identification.

In addition, recently developed anti-parasitic agents targeting particular pathways, which serve as lead compounds for further drug development, are presented.

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