Therapeutic Oligonucleotides : Transcriptional and Translational Strategies for Silencing Gene Expression, Volume 1058 Paperback / softback

Edited by Yoon S. (National Cancer Institute, National Institutes of Health, Bethesda, MD, USA) Cho-Chung, Alan M. (University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania) Gewirtz, Cy A. (Albert Einstein College of Medicine, New York, USA) Stein

Part of the Annals of the New York Academy of Sciences series

Paperback / softback

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The potential for the development of therapeutic oligonucleotides into clinical medicines and their use as basic research tools are explored in this volume, which is the proceedings of the 7th NIH Symposium on Therapeutic Oligonucleotides.

The focus is on antisense, RNAi, triple-helix, gene repair, DNA chips, and CpG immune modulatory oligonucleotides. Specific chapters address designing better siRNAs, splice switching oligonucleotides, selective delivery of oligonucleotides, and medicinal drugs by receptor-mediated endocytosis, development of a function overriding siRNA silencing in mammalian cells, transcription factor decoys, and modified oligonucleotide hybridization and genetic insertion. NOTE: Annals volumes are available for sale as individual books or as a journal.

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