Statistical Approaches to Gene x Environment Interactions for Complex Phenotypes Hardback
Edited by Michael (Rollins Professor and Chair, Emory University) Windle
Part of the The MIT Press series
Hardback
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Diverse methodological and statistical approaches for investigating the role of gene-environment interactions in a range of complex diseases and traits. Findings from the Human Genome Project and from Genome-Wide Association (GWA) studies indicate that many diseases and traits manifest a more complex genomic pattern than previously assumed.
These findings, and advances in high-throughput sequencing, suggest that there are many sources of influence-genetic, epigenetic, and environmental.
This volume investigates the role of the interactions of genes and environment (G x E) in diseases and traits (referred to by the contributors as complex phenotypes) including depression, diabetes, obesity, and substance use.
The contributors first present different statistical approaches or strategies to address G x E and G x G interactions with high-throughput sequenced data, including two-stage procedures to identify G x E and G x G interactions, marker-set approaches to assessing interactions at the gene level, and the use of a partial-least square (PLS) approach.
The contributors then turn to specific complex phenotypes, research designs, or combined methods that may advance the study of G x E interactions, considering such topics as randomized clinical trials in obesity research, longitudinal research designs and statistical models, and the development of polygenic scores to investigate G x E interactions. ContributorsFatima Umber Ahmed, Yin-Hsiu Chen, James Y.
Dai, Caroline Y. Doyle, Zihuai He, Li Hsu, Shuo Jiao, Erin Loraine Kinnally, Yi-An Ko, Charles Kooperberg, Seunggeun Lee, Arnab Maity, Jeanne M.
McCaffery, Bhramar Mukherjee, Sung Kyun Park, Duncan C.
Thomas, Alexandre Todorov, Jung-Ying Tzeng, Tao Wang, Michael Windle, Min Zhang
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Available to Order - This title is available to order, with delivery expected within 2 weeks
- Format:Hardback
- Pages:304 pages, 43 b&w illus.; 86 Illustrations, unspecified
- Publisher:MIT Press Ltd
- Publication Date:08/07/2016
- Category:
- ISBN:9780262034685
Information
-
Available to Order - This title is available to order, with delivery expected within 2 weeks
- Format:Hardback
- Pages:304 pages, 43 b&w illus.; 86 Illustrations, unspecified
- Publisher:MIT Press Ltd
- Publication Date:08/07/2016
- Category:
- ISBN:9780262034685